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2019 Vol.32, Issue 5 Preview Page

Research Article

Anti-Cancer Activity of the Leave Extracts of Rodgersia podophylla through β-catenin Proteasomal Degradation in Human Cancer Cells

도깨비부채(Rodgersia podophylla) 잎 추출물의 인간 암세포의 β-catenin 분해 유도 활성

Ha Na Kim1
,
Jeong Dong Kim1
,
Ho-Jun Son2
,
Gwang Hun Park2
,
Hyun Ji Eo3
,
Jin Boo Jeong4*
김 하나1
,
김 정동1
,
손 호준2
,
박 광훈2
,
어 현지3
,
정 진부4*
1Graduate Student , Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립산림과학원 산림약용자원연구소, 연구사
3국립산림과학원 산림약용자원연구소, 박사후연구원
4국립안동대학교 생약자원학과, 교수
* Corresponding Author
31 October 2019. pp. 442-447
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Abstract

In this study, we evaluated the effect of Rodgersia podophylla leave extracts (RPL) on β-catenin level in human cancer cells. RPL dose-dependently inhibited cell proliferation in SW480, A549, MDA-MB-231, PC-3 and AsPC-1 cells. RPL dramatically decreased β-catenin protein level in all cancer cells. However, decreased level of β-catenin mRNA expression was observed in A549 and AsPC-1 cells. In addition, RPL dramatically attenuated cyclin D1 mRNA expression in all cancer cells. MG132 decreased the downregulation of β-catenin protein level induced by RPL in all cancer cells, while RPL-induced downregulation of β-catenin was inhibited by the inhibition of GSK-3β by LiCl in MDA-MB-231 cells. RPL phosphorylated β-catenin and GSK-3β. In addition, the inhibition of GSK-3β by LiCl attenuated RPL-induced β-catenin phosphorylation. Based on these findings, RPL may be a potential candidate for the development of chemopreventive or therapeutic agents for human cancer.

Keywords
Anticancer activity
β-Catenin
Cancer chemoprevention
Rodgersia podophylla
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 32
  • No :5
  • Pages :442-447
  • Received Date : 2019-06-24
  • Revised Date : 2019-08-23
  • Accepted Date : 2019-08-27
  • DOI :https://doi.org/10.7732/kjpr.2019.32.5.442
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