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2022 Vol.35, Issue 2 Preview Page

Research Article

Anti-Obesity Effect of Parthenocissus tricuspidata (Siebold & Zucc.) Planch Stem Extracts

소나무 담쟁이덩굴(Parthenocissus tricuspidata (Siebold & Zucc.) Planch) 줄기 추출물의 항비만 효과

Joo Ho Yeo1
,
Yu Ju Hyeong1
,
Min Yeong Choi1
,
Jae Won Lee2
,
Na Gyeong Geum1
,
Mi-Yun An3
,
Chuleui Jung4
,
Jin Boo Jeong5*
여 주호1
,
유 주형1
,
최 민영1
,
이 재원2
,
금 나경1
,
안 미연3
,
정 철의4
,
정 진부5*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Post-doc, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
3Researcher, National Forest Seed and Variety Center, Chungju 27495, Korea
4Professor, Department of Plant Medicals, Andong National University, Andong 36729, Korea
5Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립안동대학교 생약자원학과, 박사후연구원
3국립산림품종관리센터, 연구원
4국립안동대학교 식물의학과, 교수
5국립안동대학교 생약자원학과, 교수
*Corresponding Author
1 April 2022. pp. 380-384
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Abstract

In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.

Keywords
Adipocytes
Anti-obesity activity
Parthenocissus tricuspidata (Siebold & Zucc.) Planch
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 35
  • No :2
  • Pages :380-384
  • Received Date : 2022-02-11
  • Revised Date : 2022-02-24
  • Accepted Date : 2022-03-01
  • DOI :https://doi.org/10.7732/kjpr.2022.35.2.380
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