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2020 Vol.33, Issue 4 Preview Page

Research Article

Effects of Ethanol Extract from Lathyrus palustris on Anti-inflammation Response of RAW 264.7 Cell

RAW 264.7 대식세포 염증반응에 대한 털연리초 에탄올 추출물의 항염증 효과

Jung Hwan Nam1*
남 정환1*
1Researcher, Highland Agriculture Research Institute, National Institute of Crop Science Rural Development Administration, Pyeongchang 25342, Korea
1농촌진흥청 국립식량과학원 고령지농업연구소
* Corresponding Author
1 August 2020. pp. 287-292
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Abstract

Lathyrus palustris often used as a treatment for inflammation of the kidneys in Korean traditional medication. Generally, drugs for arthritis have anti-inflammatory and antinociceptive properties. However, the validity of the anti-inflammatory effect has not been scientifically investigated so far. Therefore, the purpose of the research was to investigate the latent anti-inflammatory ability of L. palustris using the ethanol extract. To evaluate the anti-inflammatory activities, we examined the inflammatory arbitrators such as a nitric oxide (NO) and prostaglandin E2 (PGE2) on RAW 264.7 cells. Our results indicated that ethanol extract significantly inhibited the lipopolysaccharide E (LPS) derived PGE2 production in RAW 264.7 cell. The inhibitory activity of ethanol extract for PGE2 tests with inhibition ratio showed in 40 ㎍/mL. Overall, PGE2 tests had a higher inhibitory effect on inflammation than NO tests. This result anticipated that the ethanol extract from L. palustris is a good candidate for developing the origin of anti-inflammatory agents.

Keywords
Anti-inflammatory
Lathyrus palustris
NO
PGE2
RAW 264.7 cell
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 33
  • No :4
  • Pages :287-292
  • Received Date : 2020-07-02
  • Revised Date : 2020-07-16
  • Accepted Date : 2020-07-17
  • DOI :https://doi.org/10.7732/kjpr.2020.33.4.287
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