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2021 Vol.34, Issue 6 Preview Page

Research Article

Immunostimulatory Activity of Hibiscus manihot Flower in Mouse Macrophages, RAW264.7 Cells
Na Gyeong Geum1
,
Ju Hyeong Yu2
,
Joo Ho Yeo2
,
Min Yeong Choi2
,
Gwang Hun Park3
,
Se Chul Hong4
,
Jin Boo Jeong5*
1Master’s Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
2Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Senior Researcher, Gumi Electronics & Information Technology Research Institute, Gumi 39171, Korea
5Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
*Corresponding Author
1 December 2021. pp. 536-541
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Abstract

In this study, we investigated whether Hibiscus manihot flowers (HMF) exhibits immunostimulatory activity in RAW264.7 cells. HMF increased the production of immunostimulatory factors such as NO, iNOS, IL-1β and TNF-α in RAW264.7 cells. TLR2 and TLR4 blocked HMF-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of MAPK signaling pathway reduced HMF-mediated production of immunostimulatory factors. From these results, HMF is thought to promote the production of immunostimulatory factors through activating TLR2/4/MAPK signaling in macrophages. It is believed that HMF can be developed as an agent related to immune enhancement in the future.

Keywords
Hibiscus manihot flowers
Immune enhancement
Macrophages
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :6
  • Pages :536-541
  • Received Date : 2021-10-15
  • Revised Date : 2021-11-09
  • Accepted Date : 2021-11-14
  • DOI :https://doi.org/10.7732/kjpr.2021.34.6.536
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