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2021 Vol.34, Issue 4 Preview Page

Research Article

Effect of Fruits from Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee on Macrophage Activation

산돌배(Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee) 열매의 대식세포 활성화 유도 활성

Na Gyeong Geum1
,
Jin Boo Jeong2*
금 나경1
,
정 진부2*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립안동대학교 생약자원학과, 교수
*Corresponding Author
1 August 2021. pp. 377-383
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Abstract

In this study, we investigated in vitro immunostimulatory activity of fruit extracts from Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee (PUF) using mouse macrophage RAW264.7 cells. PUF increased the production of immunostimulatory factors such as NO, iNOS, IL-1β, IL-6 and TNF-α, and phagocytic activity in RAW264.7 cells. The inhibition of TLR2 and TLR4 blocked PUF-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of MAPKs signaling pathway reduced PUF-mediated production of immunostimulatory factors. From these results, PUF may have immunostimulatory activity via TLR2/4-mediated activation of MAPKs signaling pathway. Therefore, PUF expected to be used as a potential immune-enhancing agent.

Keywords
Immunity
Immunostimulatory activity
Macrophage activation
Pyrus ussuriensis
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :4
  • Pages :377-383
  • Received Date : 2021-05-27
  • Revised Date : 2021-06-17
  • Accepted Date : 2021-06-22
  • DOI :https://doi.org/10.7732/kjpr.2021.34.4.377
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