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2021 Vol.34, Issue 5 Preview Page

Research Article

Bioavailability and Anti-inflammatory Effect of Fermented Red Ginseng in BALB/c Mouse

BALB/c 마우스에서 발효 홍삼 Ginsenoside의 생체이용율과 항염효과

Eun Kyu Lee1
,
Chu Hyun Bae2
,
Yu Jin Kim2
,
Soo-Dong Park2
,
Jae-Jung Shim2
,
Youngbob Yu3
,
Jung-Lyoul Lee2*
이 은규1
,
배 주현2
,
김 유진2
,
박 수동2
,
심 재중2
,
유 영법3
,
이 정열2*
1Graduate Student, Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan 15588, Korea
2Researcher, Central Institute, hy Co., Ltd., Yongin 17086, Korea
3Professor, Department of Herbal Pharmaceutical Development and Emergency Medical Rescue, Nambu University, Gwangju 62271, Korea
1한양대학교 약학과, 석사연구원
2㈜에치와이 중앙연구소, 연구원
3남부대학교 한방제약개발학과･응급구조학과, 교수
*Corresponding Author
1 October 2021. pp. 433-442
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Abstract

The fermented red ginseng by microorganism is known to increase pharmacological activity in vivo. To evaluate the bioavailablity of red ginseng fermented by probiotics, we conducted the pharmacokinetic study of ginsenoside Rb1, Rd and total ginsenosides (TG, ginsenosides Rb1 + Rd + Rg1 + F2 + Rg3 + compound K) in BALB/C mice. The AUC value of ginsenoside Rb1 in mice serum administered with 600㎎/㎏ drugs showed 21.93 ± 14.68 ng·h/mL (RGw, water extract), 275.211 ± 110.04 ng·h/mL (RGe, 50% ethanol extract) and 404.91 ± 162.57 ng·h/mL (fRGe, fermented red ginseng extract). Analysis of ginsenoside Rd also showed a higher ACU value in fRGe than in RGw or RGe. And the AUC value of total ginsenosides in mice serum treated with 600 ㎎/㎏ were observed 42.12 ± 23.44 ng·h/mL (RGw), 321.44 ± 133.5 ng·h/mL (RGe) and 537.33 ± 229.01 ng·h/mL (fRGe), respectively. Cmax value of ginsenoside Rb1 in mice administered with 600㎎/㎏ were observed 3.67 ± 3.34 ng/mL (RGw), 23.27 ± 8.81 ng/mL (RGe) and 25.52 ± 7.29 ng/mL (fRGe). These results can be considered that the fermented red ginseng has more bioavailability than that of unfermented red ginseng. In quantitative analysis of the inflammation-related cytokines IL-1β and TNF, no significant difference was found between the fermented red ginseng (fRGe) and the red ginseng (RGe).

Keywords
Anti-inflammation
Bioavailability
Fermented red ginseng
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :5
  • Pages :433-442
  • Received Date : 2021-07-23
  • Revised Date : 2021-08-02
  • Accepted Date : 2021-08-10
  • DOI :https://doi.org/10.7732/kjpr.2021.34.5.433
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