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2022 Vol.35, Issue 6 Preview Page

Research Article

Vasodilatory Effect of Complex Saponin Extracted from Platycodon grandiflorum and Glycyrrhiza uralensis Mixture Extract
Jung-Hwan Nam1*
1Researcher, Highland Agriculture Research Institute, National Institute of Crop Science Rural Development Administration, Pyeongchang 25342, Korea
*Corresponding Author
30 December 2022. pp. 713-719
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Abstract

Platycodon grandiflorum and Glycyrrhiza uralensis contain several bioactive compounds, such as saponin, oleanolic acid, and flavone. P. grandiflorum and G. uralensis have traditionally been used to treat disorders related to blood pressure, diabetes, and counteracting poison, and they have antinociceptive and antiinflammatory properties. However, the validity of complex saponin’s vasodilatory effect has not been scientifically investigated. Therefore, this study explores the vasodilatory effect of complex saponin extracted from P. grandiflorum and G. uralensis mixture extract on rabbit carotid arteries. To this end, arterial rings with intact or damaged endothelium were used in an organ bath experiment and contracted by endothelin. Complex saponins, the major active constituents of P. grandiflorum and G. uralensis mixture extract, exhibited a moderate vasodilatory effect on the rabbit’s basilar arteries. Therefore, treatment with complex saponin extracted from P. grandiflorum and G. uralensis mixture extract may selectively accelerate cerebral blood flow through basilar arterial dilation. Overall, the findings suggest that the extracted complex saponins can serve as vasodilator sources.

키워드
Basilar artery
Complex saponin
Endothelin
Glycyrrhiza uralensis
Platycodon grandiflorum
Vasodilatory effect
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 35
  • No :6
  • Pages :713-719
  • Received Date : 2022-10-18
  • Revised Date : 2022-10-31
  • Accepted Date : 2022-11-02
  • DOI :https://doi.org/10.7732/kjpr.2022.35.6.713
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