Immune-enhancing Activity of Water Extracts for Each Part of 13 Species (Rhamnaceae) in Korea

Dae Hui Jeong; Min Yeong Choi; Gwang Hun Park

doi:10.7732/kjpr.2024.37.1.001

All Issue

2024 Vol.37, Issue 1 Next Page

Immune-enhancing Activity of Water Extracts for Each Part of 13 Species (Rhamnaceae) in Korea 국내 갈매나무과 13종에 대한 부위별 물 추출물의 면역 증진 활성

1 February 2024. pp. 1-10

PDF XML

Abstract

This studied the immune-enhancing activity properties of water extracts from the leaves, branches, and fruit of 13 species (Rhamnaceae) collected during the bearing season (Berchemia berchemiifolia, B. floribunda, Hovenia dulcis, Paliurus ramosissimus, Rhamnella franguloides, Rhamnus crenata, R. davurica, R. koraiensis, R. parvifolia, R. ussuriensis, R. yoshinoi, Sageretia thea, and Ziziphus jujube). Immune-enhancing activity were studied using the nitric oxide (NO) production in RAW264.7 cells. Extracts of B. berchemiifolia, H. dulcis, R. franguloides, R. crenata, R. davurica, R. ussuriensis and S. thea showed strong immune-enhancing activity through NO production. In addition, the expression of immune enhancement-related cytokine genes (NOS, COX-2, IL-1β, IL-6 and TNF-α) were confirmed through PCR-electrophoresis. The results of this study suggest that Rhamnaceae extracts can be used as natural antioxidants and immune enhancer.

Keywords

Cytokine

Immune-enhancing

Nitric oxide

Rhamnaceae

References

Anggriani, N., M.Z. Ndii, R. Amelia, W. Suryaningrat and M.A. Aji Pratama. 2022. A mathematical COVID-19 model considering asymptomatic and symptomatic classes with waning immunity. Alex. Eng. J. 61(1):113-124. 10.1016/j.aej.2021.04.104PMC9703878

Apetoh, L., F. Ghiringhelli, A. Tesniere, M. Obeid, C. Ortiz, A. Criollo and L. Zitvogel. 2017. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13(9):1050-1059. 10.1038/nm162217704786

Barbara, J.A., X. Van Ostade and A.F. Lopez. 1996. Tumour necrosis factor-alpha (TNF-α): the good, the bad and potentially very effective. Immunol. Cell Biol. 74(5):434-443. 10.1038/icb.1996.738912006

Blanco-Melo, D., B.E. Nilsson-Payant, W.C. Liu, S. Uhl, D. Hoagland, R. Møller and R.A. Albrecht. 2020. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell 181(5):1036-1045. 10.1016/j.cell.2020.04.02632416070PMC7227586

Bohlen, H.J. 2015. Nitric oxide and the cardiovascular system. Compr. Physiol. 5(2):808-823.

Chang, C.S. and H. Kim. 2001. The distribution of the woody plants of South Korea based on herbarium (SNUA) material of the arboretum (VII) - Rhamnaceae-. Bull. Seoul Natl. Univ. Arbor. 21:1-15.

Choo, G.C. 1992. Systematic studies of the family Rhamnaceae in Korea. Department of Forestry, Ph.D. Thesis, Konkuk Univ., Korea. pp. 22-70.

Choo, G.C., S.I. Kim, Y. Chung and S. Lee. 1993. A palynotaxonomic study of the Korean Rhamnaceae. Korean J. Pl. Taxon. 23(3):175-188 (in Korean). 10.11110/kjpt.1993.23.3.175

Eo, H.J, G.H. Park and J.B. Jeong. 2021. In vitro macrophage activation by Sageretia thea fruits through TLR2/TLR4-dependent activation of MAPK, NF-κB and PI3K/AKT signaling in RAW264.7 cells. Food Agric. Immunol. 32(1):15-32. 10.1080/09540105.2020.1857339

Geum, N.G., H.J. Eo, H.J. Kim, G.H. Park, H.J. Son and J.B. Jeong. 2020. Immune-enhancing activity of Hydrangea macrophylla subsp. serrata leaves through TLR4/ROS-dependent activation of JNK and NF-κB in RAW264.7 cells and immunosuppressed mice. J. Funct. Foods 73:104139. 10.1016/j.jff.2020.104139

Hirayama, D., T. Iida and H. Nakase. 2018. The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. Int. J. Mol. Sci. 19(1):92. 10.3390/ijms1901009229286292PMC5796042

Ji, S.Y., D.H. Kwon, H.J. Hwang and Y.H. Choi. 2023. Evaluation of immune enhancing activity of luthione, a reduced glutathione, in RAW 264.7 macrophages. J. Life Sci. 33(5):397-405 (in Korean).

Kang, Y.G., H.J. Eo, D.S. Kim, Y.K. Park, J.H. Song and G.H. Park. 2020. Berchemia floribunda-mediated proteasomal degradation of cyclin D1 via GSK3β-dependent threonine-286 phosphorylation in human colorectal cancer cells. Korean J. Plant Res. 33(4):271-278 (in Korean).

Kim, D.S., H.J. Eo, Y.G. Kang and G.H. Park. 2021. Anti-inflammatory effect of Berchemia berchemiae folia leaves through inhibition of NF-κB and MAPK signaling activation in LPS-stimulated RAW264.7 cells. Korean J. Plant Res. 34:31-36 (in Korean).

Kim, H.N., G.H. Park, J.D. Kim, S.B. Park, H.J. Eo and J.B. Jeong. 2019a. Effect of the extracts from the leaves and branches of Sageretia thea on β-catenin proteasomal degradation in human colorectal and lung cancer cells. Korean J. Plant Res. 32(2):153-159 (in Korean).

Kim, H.N., G.H. Park, S.B. Park, J.D. Kim, H.J. Eo, H.J. Son, J.H. Song and J.B. Jeong. 2019b. Sageretia thea inhibits iflammation through suppression of NF-κB and MAPK and activation of Nrf2/HO-1signaling pathways in RAW264.7 cell. Am. J. Chin. Med. 47(2):385-403. 10.1142/S0192415X1950019830834779

Kim, S.M., S.H. Kang, J.Y. Ma and J.H. Kim. 2006. A study on the extraction and efficacy of bioactive Compound from Hovenia dulcis. Korean J. Biotechnol. Bioeng. 21(1):11-15 (in Korean).

Ma, Q., S. LI, C. Bi, Z. Hao, C. Sun and N. Ye. 2017. Complete chloroplast genome sequence of a major economic species, Ziziphus jujube (Rhamnaceae). Curr. Genet. 63(1):117-129. 10.1007/s00294-016-0612-427206980

Marshall, J.S., R. Warrington, W. Watson and H.L. Kim. 2018. An introduction to immunology and immunopathology. Allergy Asthma Clin. Immunol. 14(2):49. 10.1186/s13223-018-0278-130263032PMC6156898

Medan, D. and C. Schirarend. 2004. Rhamnaceae. In Kubitzki, K. (ed.), The Families and Genera of Vascular Plants. Vol. VI. Springer, New York, NY (USA). pp. 320-338. 10.1007/978-3-662-07257-8_37

Medzhitov, R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449:819-826. 10.1038/nature0624617943118

Medzhitov, R. and C. Janeway. 2000. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173:89-97. 10.1034/j.1600-065X.2000.917309.x10719670

Mills, C.D. and K. Ley. 2014. M1 and M2 macrophages: The chicken and the egg of immunity. J. Innate Immun. 6(6):716-726. 10.1159/00036494525138714PMC4429858

Mills, C.D., L.L. Lenz and K. Ley. 2015. Macrophages at the fork in the road to health or disease. Front. Immunol. 6:59. 10.3389/fimmu.2015.00059

Monmai, C., A.Y. Jang, J.E. Kim, S.M. Lee, S. You, S. Kang and W.J Park. 2020. Immunomodulatory activities of body wall fatty acids extracted from Halocynthia aurantium on RAW264.7 cells. J. Microbiol. Biotechnol. 30(12):1927-1936. 10.4014/jmb.2007.0703233046674PMC9728411

Namkoong, S., S.A. Jang, E.H. Sohn, J.P. Bak, E. Sohn, H.J. Koo, W.J. Yoon, J.E. Kwon, Y.J. Jeong, X. Meng, H.S. Han and S.C. Kang. 2015. Comparative study of Litsea japonica leaf and fruit extract on the anti-inflammatory effects. Korean J. Plant Res. 28(2):145-152 (in Korean). 10.7732/kjpr.2015.28.2.145

Pedersen, S.F. and Y.C. Ho. 2020. SARS-CoV-2: a storm is raging. J. Clin. Investig. 130(5):2202-2205. 10.1172/JCI13764732217834PMC7190904

Prichard, E.C. 1955. Morphological studies in Rhamnaceae. J. Elisha Mitchell Sci. Soc. 71(1):82-106.

Radak, Z., H. Naito and A.W. Taylor. 2012. Nitric Oxide: Is it the cause of muscle soreness?. Nitric Oxide 26(2):89-94. 10.1016/j.niox.2011.12.00522227257

Seillet, C., G.T. Belz and L.A. Mielke. 2014. Complexity of cytokine network regulation of innate lymphoid cells in protective immunity. Cytokine 70(1):1-10. 10.1016/j.cyto.2014.06.00224972988

Sharma, J.N., A. Al-Omran and S.S. Parvathy. 2007. Role of nitric oxide in inflammatory diseases. Inflammopharmacology 15(6):252-259. 10.1007/s10787-007-0013-x18236016

Shen, C.Y., W.L. Zhang and J.G. Jiang. 2017. Immune-enhancing activity of polysaccharides from Hibiscus sabdariffa Linn. via MAPK and NF-kB signaling pathways in RAW264.7 cells. J. Funct. Foods 34:118-129. 10.1016/j.jff.2017.03.060

Sladkova, T. and F. Kostolansky. 2006. The role of cytokines in the immune response to influenza A virus infection. Acta Virol. 50(3):151-162.

Sun, L., X. Wang, J. Saredy, Z. Yuan, X. Yang and H. Wang. 2020. Innate-adaptive immunity interplay and redox regulation in immune response. Redox Biol. 37:101759. 10.1016/j.redox.2020.10175933086106PMC7575795

Tripathi, P., L. Kashyap and V. Singh. 2007. The role of nitric oxide in inflammatory reactions. FEMS Immunol. Med. Microbiol. 51(3):443-452. 10.1111/j.1574-695X.2007.00329.x17903207

Wagner, H. 1990. Search for plant derived natural products with immunostimulatory activity (recent advances). Pure & Appl. Chem. 62(7):1217-1222. 10.1351/pac199062071217

Wauters, E., K. Thevissen, C. Wouters, F.M. Bosisio, F. De Smet, J. Gunst and A.D. Garg. 2020. Establishing a unified COVID-19 "immunome": Integrating coronavirus pathogenesis and host immunopathology. Front. Immunol. 11:1642. 10.3389/fimmu.2020.0164232719686PMC7347900

Woo, H.S., S.M. Lee, J.D. Heo, M.S. Lee, Y.S. Kim and D.W. Kim. 2018. Anti-inflammatory activity of extracts of hovenia dulcis on lipopolysaccharides-stimulated RAW264.7 cells. Korean J. Plant Res. 31(5):466-477 (in Korean).

Xue, Q., Y. Yan, R. Zhang and H. Xiong. 2018. Regulation of iNOS on immune cells and its role in diseases. Int. J. Mol. Sci. 19(2):3805. 10.3390/ijms1912380530501075PMC6320759

Yoo, S.A., O.K. Kim, D.E. Nam, Y. Kim, H. Baek and W. Jun. 2014. Immunomodulatory effects of fermented Curcuma longa L. extracts on RAW264.7 cells. J. Korean Soc. Food Sci. Nutr. 43(2):216-223 (in Korean). 10.3746/jkfn.2014.43.2.216

Information

Publisher :The Plant Resources Society of Korea
Publisher(Ko) :한국자원식물학회
Journal Title :Korean Journal of Plant Resources
Journal Title(Ko) :한국자원식물학회지
Volume : 37
No :1
Pages :1-10
Received Date : 2023-09-06
Revised Date : 2023-11-08
Accepted Date : 2023-11-08
DOI :https://doi.org/10.7732/kjpr.2024.37.1.001

Korean Journal of Plant ResourcesISSN:1226-3591(Print) 2287-8203(Online)한국자원식물학회

All Issue