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2019 Vol.32, Issue 4 Preview Page

Research Article

Protective Effect of Water Extract of Leonurus japonicus Houttuyn against HCl/EtOH-induced Gastric Mucosal Damage and Genotoxicity Evaluation using Micronucleus Test

익모초 물 추출물의 위염 예방효과 및 소핵시험을 이용한 유전독성 평가

Jong Hyun Nho1*
,
Hyun Joo Lee1*
,
Ji Hun Jang2
,
Beo Dul Yang3
,
Kyeong Wan Woo1
,
A Hyeon Kim3
,
Jae Wan Seo3
,
Young Sun Kim3
,
Hyun Woo Cho4
,
Ho Kyung Jung2**
노 종현1*
,
이 현주1*
,
장 지훈2
,
양 버들3
,
우 경완1
,
김 아현3
,
서 재완3
,
김 선영3
,
조 현우4
,
정 호경2**
1Researcher, National Institute for Korean Medicine Development, Jangheung-gun 59338, Korea
2Senior Researcher, National Institute for Korean Medicine Development, Jangheung-gun 59338, Korea
3Associate Researcher, National Institute for Korean Medicine Development, Jangheung-gun 59338, Korea
4Director, National Institute for Korean Medicine Development, Jangheung-gun 59338, Korea
1한국한의약진흥원, 선임연구원
2한국한의약진흥원, 책임연구원
3한국한의약진흥원, 주임연구원
4한국한의약진흥원, 본부장
* First Author
** Corresponding Author
31 August 2019. pp. 282-289
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Abstract

Gastritis is an inflammatory disease involving the stomach and is caused by several factors, including stress, non-steroidal anti-inflammatory drugs such as aspirin, liquor, and Helicobacter pylori. In Korea, Leonurus japonicus Houttuyn (LJW) has been used as traditional medicine for vaginal bleeding, hematuria, and bruise. Previous studies have reported that LJW exhibited hepatoprotective, cardioprotective, and anti-hyperlipidemic effect. However, the effect of the water extract of LJW on gastritis was not elucidated. Thus, we evaluated the anti-gastric effect and genotoxicity of LJW. LJW effectively prevented the degeneration of surface mucous cells and glandular epithelial cells and vascular congestion induced by HCl/EtOH. Micronucleus assay indicated that the rate of micronucleated polychromatic erythrocytes/polychromatic erythrocytes was not significantly different compared that of the control. Further experiments are required to determine the role of LJW in the gastric injury process such as cyclooxygenase signaling pathway and the secretion of mucus in the stomach.

Keywords
Gastiritis
Genotoxicity
Leonurus japonicus Houttuyn
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 32
  • No :4
  • Pages :282-289
  • Received Date : 2019-03-12
  • Revised Date : 2019-06-19
  • Accepted Date : 2019-07-10
  • DOI :https://doi.org/10.7732/kjpr.2019.32.4.282
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