All Issue

2019 Vol.32, Issue 6 Preview Page

Research Article

The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions
Noh-Yil Myung1
,
Su-Jin Kim2*
1Professor, Department of Oriental Medicine and Healthcare, Wonkwang Digital University, Iksan 54538, Korea
2Professor, Department of Biotechnology and Convergence, Daegu Haany University, Kyungsan 38578, Korea
* Corresponding Author
31 December 2019. pp. 705-713
PDF XML Citation
Abstract

Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor -κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.

Keywords
Atopic dermatitis
Avocado
Inflammation
References
1
Allam, J.P. and N. Novak. 2006. The pathophysiology of atopic eczema. Clin. Exp. Dermatol. 31:89-93.
10.1111/j.1365-2230.2005.01980.x16309494
2
Au, R.Y., T.K. Al-Talib, A.Y. Au, P.V. Phan and C.G. Frondoza. 2007. Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthr. Cartilage 15:1249-1255.
10.1016/j.joca.2007.07.00917845860
3
Berke, R., A. Singh and M. Guralnick. 2012. Atopic dermatitis: an overview. Am. Fam. Physician 86:35-42.
4
Bhuyan, D.J., QV. Vuong, A.C. Chalmers, I.A. Van Altena, M.C. Bowyer and C.J. Scarlett. 2016. Investigation of phytochemicals and antioxidant capacity of selected Eucalyptus species using conventional extraction. Chem. Pap. 70: 567-575.
5
Bieber, T. 2008. Atopic dermatitis. N. Engl. J. Med. 358:1483- 1494.
10.1056/NEJMra07408118385500
6
Bouchier-Hayes, L. and S.J. Martin. 2004. CARDINAL roles in apoptosis and NFkappaB activation. Vitam. Horm. 67: 133-147.
10.1016/S0083-6729(04)67008-7
7
Brenninkmeijer, E.E., P.I. Spuls, C.M. Legierse, R. Lindeboom, J.H. Smitt and J.D. Bos. 2008. Clinical differences between atopic and atopiform dermatitis. J. Am. Acad. Dermatol. 58:407-414.
10.1016/j.jaad.2007.12.00218280337
8
Bunikowski, R., K. Gerhold, M. Bräutigam, E. Hamelmann, H. Renz and U. Wahn. 2001. Effect of low-dose cyclosporin a microemulsion on disease severity, interleukin-6, interleukin-8 and tumor necrosis factor alpha production in severe pediatric atopic dermatitis. Int. Arch. Allergy Immunol. 125:344-348.
10.1159/00005383611574757
9
Das, A. and S. Panda. 2017. Use of topical corticosteroids in dermatology: an evidence-based approach. Indian J. Dermatol. 62:237-250.
10.1007/978-981-10-4609-4_4
10
Fedenko, E.S., O.G. Elisyutina, T.M. Filimonova, M.N. Boldyreva, O.V. Burmenskaya, O.Y. Rebrova, A.A. Yarilin and R.M. Khaitov. 2011. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Self Nonself. 2:120-124.
10.4161/self.2.2.1693922299064PMC3268998
11
Gomez, G. 2019. Current strategies to inhibit high affinity fcεri-mediated signaling for the treatment of allergic disease. Front Immunol. 10:175-185.
10.3389/fimmu.2019.0017530792720PMC6374298
12
Gold, M.S. and A.S. Kemp. 2005. Atopic disease in childhood. Med. J. Aust. 182:298-304.
10.5694/j.1326-5377.2005.tb06707.x15777148
13
Gilmore, T.D. and M.R. Garbati. 2011. Inhibition of NF-κB signaling as a strategy in disease therapy. Curr. Top. Microbiol. Immunol. 349:245-263.
10.1007/82_2010_10521113699
14
Hanifin, J.M., M. Thurston, M. Omoto, R. Cherill, S.J. Tofte and M. Graeber. 2001. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp. Dermatol. 10:11-18.
10.1034/j.1600-0625.2001.100102.x11168575
15
Hawiger, J. 2001. Innate immunity and inflammation: a transcriptional paradigm. Immunol. Res. 23:99-109.
10.1385/IR:23:2-3:099
16
Imaizumi, A., T. Kawakami, F. Murakami, Y. Soma and M. Mizoguchi. 2003. Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): Changes in blood histamine and tryptase levels. J. Dermatol. Sci. 33:23-29.
10.1016/S0923-1811(03)00132-4
17
Kim, S.J., J.Y. Kee, I.Y. Choi, M.C. Kim, D.S. Kim, Y.D. Jeon, S.G. Kim, B.S. Kim, H.J. Jung, H.M. Kim, S.H. Hong and J.Y. Um. 2011. Insamhodo-tang, a traditional Korean medicine, regulates mast cell-mediated allergic inflammation in vivo and in vitro. J. Ethnopharmacol. 134:339-347.
10.1016/j.jep.2010.12.02321184820
18
Lee, J.W. and Y.J. Kang. 2018. Anti-inflammatory effects of Abeliophyllum distichum flower extract and associated MAPKs and NF-κB pathway in raw264.7 cells. Korean J. Plant Res. 31:202-210.
19
Kim, S.J., M.C. Kim, J.Y. Um and S.H. Hong. 2010. The beneficial effect of vanillic acid on ulcerative colitis. Molecules 15:7208-7217.
10.3390/molecules1510720820959795PMC6259113
20
Lee, K.S., E.S. Jeong, S.H Heo, J.H. Seo, D.G. Jeong and Y.K. Choi. 2010. A novel model for human atopic dermatitis: application of repeated DNCB patch in BALB/c mice, in comparison with NC/Nga mice. Lab. Anim. Res. 26:95-102.
10.5625/lar.2010.26.1.95
21
Lamkanfi, M., M. Kalai, X. Saelens, W. Declercq and P. Vandenabeele. 2004. Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J. Biol. Chem. 279:24785-24793.
10.1074/jbc.M40098520015039421
22
Leung, D.Y. and T. Bieber. 2003. Atopic dermatitis. Lancet 361:151-160.
10.1016/S0140-6736(03)12193-9
23
Lu, Q.Y., J.R Arteaga, Q. Zhang, S. Huerta, V.L. Go and D. Heber. 2005. Inhibition of prostate cancer cell growth by an avocado extract: Role of lipid-soluble bioactive substances. J. Nutr. Biochem. 16:23-30.
10.1016/j.jnutbio.2004.08.00315629237
24
Minami, K. and C.A. Kamei. 2004. Chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int. Immunopharmacol. 4:101-108.
10.1016/j.intimp.2003.10.01314975364
25
Nomura, I., B. Gao, M. Boguniewicz, M.A. Darst, J.B. Travers and D.Y. Leung. 2003. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J. Allergy Clin. Immunol. 112:1195-1202.
10.1016/j.jaci.2003.08.04914657882
26
Pahua-Ramos, M.E., A. Ortiz-Moreno, G. Chamorro-Cevallos, M.D. Hernandez-Navarro, L. Garduno-Siciliano, H. Necoechea- Mondragon and M. Hernandez-Ortega. 2012. Hypolipidemic effect of avocado (Persea americana Mill) seed in a hypercholesterolemic mouse model. Plant Foods Hum. Nutr. 67:10-16.
10.1007/s11130-012-0280-622383066
27
Rosenblat, G., S. Meretski, J. Segal, M.Tarshis, A. Schroeder, A. Zanin-Zhorov, G. Lion, A. Ingber and M. Hochberg. 2011. Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Arch. Dermatol. Res. 303:239-246.
10.1007/s00403-010-1088-620978772
28
Saeki, H., M. Furue, F. Furukawa, M. Hide, M. Ohtsuki, I. Katayama, R. Sasaki, H. Suto and K. Takehara. 2009. Guidelines for management of atopic dermatitis. J.  Dermatol. 36:563-577.
10.1111/j.1346-8138.2009.00706.x19785716
29
Shin, W.B., X. Dong, Y.S. Kim, J.S. Park, S.J. Kim, E.A. Go, E.K. Kim and P.J. Park. 2019. Anti-inflammatory effects of Batillaria multiformis water extracts via nf-кb and mapk signaling pathways in lps-induced raw 264.7 cells. Adv. Exp. Med. Biol. 1155:1001-1014.
10.1007/978-981-13-8023-5_8331468463
30
Shiohara, T., J. Hayakawa and Y. Mizukawa. 2004. Animal models for atopic dermatitis: are they relevant to human disease? J. Dermatol. Sci. 36:1-9.
10.1016/j.jdermsci.2004.02.01315488700
31
Siegmund, B., H.A. Lehr, G. Fantuzzi and C.A. Dinarello. 2001. IL-1 betaconverting enzyme (caspase-1) in intestinal inflammation. Porc. Natl. Acad. Sci. U.S.A. 98:13249-13254.
10.1073/pnas.23147399811606779PMC60856
32
Sugimoto, M., I. Arai, N. Futaki, Y. Hashimoto, T. Sakurai, Y. Honma and S. Nakaike. 2006. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Ngamice. Exp. Dermatol. 15:875-882.
10.1111/j.1600-0625.2006.00480.x17002684
33
Trefzer, U., M. Hofmann, W. Sterry and K. Asadullah. 2003. Cytokine and anti-cytokine therapy in dermatology. Expert opin. Biol Ther. 3:733-743.
10.1517/14712598.3.5.73312880374
34
Wang, X., H.Y. Wang and E.F. Bryan. 2005. Dysregulation of receptor interacting protein‐2 and caspase recruitment domain only protein mediates aberrant caspase‐1 activation in Huntington's disease. J. Neurosci. 25:11645-11654.
10.1523/JNEUROSCI.4181-05.200516354923PMC6726023
35
Tegeder, I., J. Pfeilschifter and G. Geisslinger. 2001. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 15:2057-2072.
10.1096/fj.01-0390rev11641233
36
Wong, C.K., C.Y. Ho, F.W. Ko, C.H. Chan, A.S. Ho, D.S. Hui and C.W. Lam. 2001. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol. 125:177-183.
10.1046/j.1365-2249.2001.01602.x11529906PMC1906135
Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 32
  • No :6
  • Pages :705-713
  • Received Date : 2019-10-11
  • Revised Date : 2019-12-17
  • Accepted Date : 2019-12-18
  • DOI :https://doi.org/10.7732/kjpr.2019.32.6.705
Journal Informaiton Korean Journal of Plant Resources Korean Journal of Plant Resources
Online Submission
  • NRF
  • KOFST
  • KISTI Current Status
  • KISTI Cited-by
  • crosscheck
  • orcid
  • ccl
Journal Informaiton Journal Informaiton - close