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2023 Vol.36, Issue 5
Evaluation of the Effects of Hangover-Releasing Agent Containing Vinegar Extract in Common Buckwheat and Tartary Buckwheat on Alcohol Metabolism and Hangover Improvement

일반메밀과 쓴메밀의 식초 추출물의 알코올 대사 및 숙취개선 효능 평가

Su Jeong Kim1†
,
Hwang Bae Sohn2†
,
A Hyun Park3
,
Jong Nam Lee4
,
Su Hyoung Park4
,
Jung Hwan Nam1
,
Do Yeon Kim1
,
Dong Chil Chang5
,
Yul Ho Kim6*
김 수정1†
,
손 황배2†
,
박 아현3
,
이 종남4
,
박 수형4
,
남 정환1
,
김 도연1
,
장 동칠5
,
김 율호6*
1Researcher, Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration, Pyeongchang 25342, Korea
2Researcher, Technology Cooperation Bureau, Rural Development Administration, Jeonju 54875, Korea
3Researcher, Efficacy research team, Southeast Medi-Chem Institute Co., Ltd, Busan 48308, Korea
4Senior Researcher, Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration, Pyeongchang 25342, Korea
5Senior Researcher, Planning & Coordination Division, National Institute of Crop Science, Rural Development Administration, Wanju 55365, Korea
6Senior Researcher, Crop Cultivation and Environment Research Division, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea
1농촌진흥청 국립식량과학원 고령지농업연구소, 농업연구사
2농촌진흥청 기술협력국 수출농업지원과, 농업연구사
3㈜동남의화학연구원, 연구원
4농촌진흥청 국립식량과학원 고령지농업연구소, 농업연구관
5농촌진흥청 국립식량과학원 기획조정과, 농업연구관
6농촌진흥청 국립식량과학원 재배환경과, 농업연구관
*Corresponding Author
†These authors contributed equally to this work.
1 October 2023. pp. 435-445
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Abstract

The aim of this study was to explore the effects of vinegar extract from seed of common buckwheat (Fagopyrum esculentum Moench) and seed of tartary buckwheat (F. tataricum Gaertner) on acute ethanol-induced hangover in Sprague-Dawley rats. Vinegar extract from buckwheat is rich choline, quercetin and its glycoside, rutin known as flavonoid antioxidants. The test extract containing buckwheat was proven to alleviate hangovers through a significant reduction in the concentration of alcohol and acetaldehyde in the context of an alcohol-induced hangover model. Hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly higher in buckwheat vinegar-treated rats than in ethanol-treated rats. Moreover, tartary buckwheat vinegar upregulated antioxidant enzyme such as superoxide dismutase and Catalase activities in liver tissues. These results suggest that buckwheat vinegar extract could alleviate ethanol-induced hangover symptoms by elevating activities related to hepatic ethanol-metabolizing enzymes against ethanol induced metabolites, and in particular, tartary buckwheat should be further developed to be a novel anti-hangover material.

Keywords
Alcohol metabolism
Buckwheat
Choline
Hangover
Rutin
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 36
  • No :5
  • Pages :435-445
  • Received Date : 2023-05-16
  • Revised Date : 2023-05-30
  • Accepted Date : 2023-05-31
  • DOI :https://doi.org/10.7732/kjpr.2023.36.5.435
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