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2023 Vol.36, Issue 1 Preview Page

Research Article

Inhibitory Activity of Wild-Simulated Ginseng against Non-Alcoholic Fatty Liver Disease in HepG-2 Cells

산양삼(Wild-Simulated Ginseng)의 비알코올성 지방간 억제활성

So Jung Park1†
,
Yurry Um2†
,
Min Yeong Choi1
,
Jin Boo Jeong3*
박 소정1†
,
엄 유리2†
,
최 민영1
,
정 진부3*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립산림과학원 산림약용자원연구소, 연구사
3국립안동대학교 생약자원학과, 교수
*Corresponding Author
†These authors contributed equally to this work.
1 February 2023. pp. 26-31
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Abstract

In this study, we investigated in vitro inhibitory activity of wild-simulated ginseng (WSG) against non-alcoholic fatty liver disease using HepG-2 cells. T0901317 treatment increased the lipid accumulation in HepG-2 cells, but WSG treatment inhibited T0901317-mediated lipid accumulation. In addition, WSG downregulated T0901317-mediated expression of SREBP-1c, ACC, FAS and SCD-1 protein. In addition, WSG increased the phosphorylation level of LKB1 and AMPK. Compound C treatment blocked WSG-mediated downregulation of SREBP-1c protein. In conclusion, WSG is considered to inhibit the accumulation of lipids and triglycerides in HepG-2 cells by inducing the activation of LKB1 and AMPK successively, thereby reducing the expression of FAS, ACC, and SCD-1 through suppression of SREBP-1c expression.

Keywords
Fatty liver disease
Non-alcoholic fatty liver disease
Wild-simulated ginseng
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 36
  • No :1
  • Pages :26-31
  • Received Date :2022. 11. 01
  • Revised Date :2022. 12. 15
  • Accepted Date : 2023. 01. 02
  • DOI :https://doi.org/10.7732/kjpr.2023.36.1.026
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