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2021 Vol.34, Issue 4 Preview Page

Research Article

Tyrosinase Inhibitory Activity and Melanin Production Inhibitory Activity of Taraxinic Acid from Taraxacum coreanum

흰민들레(Taraxacum coreanum)에서 분리한 taraxinic acid의 tyrosinase 활성저해 및 melanin 생성저해 효과

Seung Il Park1
,
Hye Ryeon Yoon1
,
Jun-Ho Shin2
,
Sung Joo Lee3
,
Do Yoon Kim4
,
Hwan Myung Lee4*
박 승일1
,
윤 혜련1
,
신 준호2
,
이 성주3
,
김 도윤4
,
이 환명4*
1Senior Researcher, C&B BIO Co. Ltd, Hwaseong 18471, Korea
2Master’s Degree Researcher, Gyeonggido Business & Science Accelerator, Bio-center, Suwon 16229, Korea
3Professor, Department of Environmental Energy Engineering, Anyang University, Anyang 14028, Korea
4Professor, Division of Cosmetic and Biotechnology, Hoseo University, Asan 31499, Korea
1㈜씨앤비바이오, 책임연구원
2경기도경제과학진흥원 바이오센터, 석사연구원
3안양대학교 환경에너지공학과, 교수
4호서대학교 화장품생명공학부, 교수
*Corresponding Author
1 August 2021. pp. 368-376
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Abstract

This study was to investigate the Taraxinic acid from Taraxacum coreanum on tyrosinase activity and melanogenesis. In B16BL6 cell, Taraxinic acid did not show cytotoxicity even at concentrations of up to 100 ㎍/mL. In addition, tyrosinase inhibitory activity and melanogenesis inhibitory activity were confirmed by stimulation with α-melanocyte stimulating hormone (α-MSH) in the presence of taraxinic acid. Taraxinic acid was added to cells at concentrations of 10, 50 and 100 ㎍/mL and treated for 48 hours to confirm tyrosinase inhibitory activity and melanin production. The tyrosinase inhibitory activity increased in proportion to the amount of the sample, and showed an inhibitory activity of about 54.5% at a concentration of 50 ㎍/mL. Melanin production decreased in proportion to the sample amount, and it was about 62.2% at the concentration of 10 ㎍/mL. From the above results, it was found that Taraxinic acid had higher tyrosinase activity and melanin synthesis inhibitory activity in melanocyte than arbutin. The results suggest that Taraxinic acid can be utilized in natural whitening cosmetics.

Keywords
Melanin
Taraxacum coreanum
Taraxinic acid
Tyrosinase
Whitening
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :4
  • Pages :368-376
  • Received Date : 2021-03-25
  • Revised Date : 2021-06-01
  • Accepted Date : 2021-06-01
  • DOI :https://doi.org/10.7732/kjpr.2021.34.4.368
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