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2025 Vol.38, Issue 5 Preview Page

Research Article

Eclipta prostrata Ameliorates the Mast Cell-mediated Allergic Inflammation via Inhibition of NF-κB / caspase-1 Activation

한련초(Eclipta prostrata)의 caspase-1 활성억제를 통한 비만세포 매개 알레르기 염증 억제 효과

Mi-Ok Yang1
,
Noh-Yil Myung2
양 미옥1
,
명 노일2
1Professor, Department of Natural Health Care & Therapy, Wonkwang Digital University Graduate School, Seoul 07448, Korea
2Professor, Department of Korean Medicine and Food Therapy, Wonkwang Digital University, Iksan 54538, Korea
1원광디지털대학교 대학원 자연건강학과, 교수
2원광디지털대학교 한방건강약선학과, 교수
*Corresponding Author
1 October 2025. pp. 517-525
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Abstract

Herbal medicine are important resources for new drug development due to their various biological properties. Eclipta prostrata (EP) is a perennial herb which is traditionally used for diseases treatment. In this study, we investigated the anti-inflammatory mechanism of EP on the mast cell-mediated allergic inflammatory response. The antioxidant activity of EP was evaluated using 2,2-diphenyl-1-picrylhydrazy (DPPH) scavenging ability and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation scavenging. To investigate EP’s pharmacological mechanisms on allergic inflammation, we assessed its impact on histamine secretion and interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α release in activated human mast cells-1 (HMC-1). Additionally, the ameliorative effects of EP on activation of nuclear factor-κB (NF-κB) and caspase-1 were measured. EP demonstrated strong DPPH and ABTS+ radical scavenging activity, and significantly reduced histamine, IL-6, IL-8 and TNF-α secretion. Moreover, EP effectively attenuated the activation of NF-κB and caspase-1 in activated- HMC-1. Conclusively, these finding suggest that EP has potential for allergic inflammatory therapy.

Keywords
Alleric inflammation
Caspase-1
Eclipta prostrata
Histamine
Nuclear factor-kappa B
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 38
  • No :5
  • Pages :517-525
  • Received Date : 2025-06-26
  • Revised Date : 2025-08-11
  • Accepted Date : 2025-08-11
  • DOI :https://doi.org/10.7732/kjpr.2025.38.5.517
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