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2020 Vol.33, Issue 4

Research Article

Effects of Cultivated Wild Panax ginseng Extract on the Proliferation, Differentiation and Mineralization of Osteoblastic MC3T3-E1 Cells

산양삼(cultivated wild Panax ginseng) 추출물이 조골세포 활성에 미치는 영향

Hyun-Ju Seo1†
,
Hyun Ji Eo2†
,
Hyun Jun Kim3
,
Kwon Seok Jeon4
,
Gwang Hun Park3
,
Se Chul Hong5
,
Jin Boo Jeong6*
서 현주1†
,
어 현지2†
,
김 현준3
,
전 권석4
,
박 광훈3
,
홍 세철5
,
정 진부6*
1Post-doc, Institute of Agricultural Science and Technology, Andong National University, Andong 36729, Korea
2Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Senior Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
5Senior Researcher, Gumi Electronics & Information Technology Research Institute, Gumi 39171, Korea
6Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 농업기술과학연구소, 박사후연구원
2국립산림과학원 산림약용자원연구소, 박사후연구원
3국립산림과학원 산림약용자원연구소, 연구사
4국립산림과학원 산림약용자원연구소, 연구관
5구미전자정보기술원, 선임연구원
6국립안동대학교 생약자원학과, 교수
* Corresponding Author
† These authors contributed equally to this work.
1 August 2020. pp. 227-236
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Abstract

Panax ginseng C.A. Meyer (P. ginseng) is known to exert a wide range of pharmacological effects both in vitro and in vivo. Although studies on ginsenoside, antioxidant activity, and anticancer effect of the cultivated wild Panax ginseng (CWP) have been conducted, there is little research on the effect of CWP extract on bone metabolism. In this study, we investigated the potential anti-osteoporotic properties of CWP on the growth and differentiation of MC3T3-E1 cells. CWP significantly increased the viability and proliferation of MC3T3-E1 cells. CWP activated intracellular alkaline phosphatase (ALP) activity in MC3T3-E1 cells. In addition, CWP increased the mineralized nodules in MC3T3-E1 cells. Furthermore, CWP increased the expression of genes such as Runx2, ALP, OPN and OCN associated with osteoblast growth and differentiation in a dose-dependent manner.

Keywords
Cultivated wild Panax ginseng
Osteoporosis
Osteoblast differentiation
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 33
  • No :4
  • Pages :227-236
  • Received Date : 2020-01-16
  • Revised Date : 2020-03-26
  • Accepted Date : 2020-04-02
  • DOI :https://doi.org/10.7732/kjpr.2020.33.4.227
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