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2018 Vol.31, Issue 2 Preview Page

Research Article

Anti-Inflammatory Effect of Biji (Soybean curd residue) on LPS-Stimulated RAW264.7 Cells

마우스 RAW264.7 세포에 대한 비지 추출물의 항염증 활성

Su Bin Park1
,
Hun Min Song13
,
Ha Na Kim1
,
Gwang Hun Park2
,
Ho-Jun Son2
,
Yurry Um2
,
Ji Ae Park13
,
Jin Boo Jeong14*
박 수빈1
,
송 훈민13
,
김 하나1
,
박 광훈2
,
손 호준2
,
엄 유리2
,
박 지애13
,
정 진부14*
1Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Baekdudaegan National Arboretum, Bonghwa 36209, Korea
4Agricultural Science and Technology Research Institute, Andong National University, Andong 36729, Korea
1안동대학교 생약자원학과
2국립산림과학원 산림약용자원연구소
3국립백두대간수목원
4안동대학교 농업과학기술연구소
* Corresponding Author
30 April 2018. pp. 117-123
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Abstract

In this study, we evaluated anti-inflammatory effect of biji in LPS-stimulated RAW264.7 cells. Biji inhibited the generation of NO and PGE2 through the suppression of iNOS and COX-2 expression. In addition, biji attenuated the expression of TNF-α and IL-1β induced by LPS. Biji blocked LPS-mediated IκB-α degradation and subsequently inhibited p65 nucleus accumulation in RAW264.7 cells, which indicates that biji inhibits NF-κB signaling. In addition, biji suppressed p38 phosphorylation induced by LPS. Our results suggests that biji may exert anti-inflammatory activity through blocking the generation of the inflammatory mediators such as NO, PGE2, iNOS, COX-2, TNF-α and IL-1β via the inhibiting the activation of NF-κB and p38. From these findings, biji has potential to be a candidate for the development of chemoprevention or therapeutic agents for inflammatory diseases.

Keywords
Anti-inflammation
Biji
MAPK
NF-κB
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :2
  • Pages :117-123
  • Received Date : 2018-01-09
  • Revised Date : 2018-02-09
  • Accepted Date : 2018-03-27
  • DOI :https://doi.org/10.7732/kjpr.2018.31.2.117
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