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2018 Vol.31, Issue 2 Preview Page

Research Article

Effect of Complex Extract Including Cornus officinalis on the Cimetidine/Ethanol-induced Erectile Dysfunction Model in Rats

산수유를 포함한 복합추출물이 cimetidine으로 발기부전을 유도한 동물모델에서 성기능 개선 효과

Ji Hun Jang1*
,
Tae Muk Kim1*
,
Mi Ok Sim1
,
Jong Hyun Nho1
,
Ho Kyung Jung1
,
Mu Jin Lee1
,
Ki Ho Lee1
,
Byeong Kwan An1
,
Hyun Woo Cho1**
장 지훈1*
,
김 태묵1*
,
심 미옥1
,
노 종현1
,
정 호경1
,
이 무진1
,
이 기호1
,
안 병관1
,
조 현우1**
1National Development Institute of Korean Medicine, Jangheung-gun 59338, Korea
1한약진흥재단
* First Author
** Corresponding Author
30 April 2018. pp. 109-116
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Abstract

Erectile dysfunction (ED), also known as impotence, is the inability to attain and sustain an erection firm enough to have sexual intercourse. Frequent ED may be a symptom of health problems including heart disease, obesity, alcoholism, stress, smoking, and depression, that need treatment. This study aimed to effect of complex extract (CPL) including Cornus officinalis on sexual function factor in the erectile dysfunction rat model. The erectile dysfuction rat model was induced by cimetidine (500 ㎎/㎏ in 5% ethanol, oral injection 2 weeks). Rats were oral administered with different concentration of CPL in rat erectile dysfunction model. As a results, sexual function factors (NO, cGMP) significantly improved in CPL treated groups (CPL-300, 600, 900 ㎎/㎏) compared to CON group. Serum testosterone was increased in a dose-dependent manner after CPL treatment. Furthermore, administrations of CPL restored lumen areas of the prostate in the erectile dysfunction rat model. These results indicated that CPL alleviated erectile dysfunction by increasing sexual function factor and testosterone in rat model. CPL could be used to natural treatement for erectile dysfunction. However, further study is required to identify active ingredient and its mechanism of erectile dysfunction.

Keywords
cGMP
Cimetidine
Cornus officinalis
Erectile dysfunction
Nitric oxide
Testosterone
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :2
  • Pages :109-116
  • Received Date : 2017-06-14
  • Revised Date : 2017-12-11
  • Accepted Date : 2017-12-12
  • DOI :https://doi.org/10.7732/kjpr.2018.31.2.109
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