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2024 Vol.37, Issue 2 Preview Page

Research Article

Hepatoprotective Effects of the Extracts of Alnus japonica Leaf on Alcohol-Induced Liver Damage in HepG2/2E1 Cells

알코올로 유도된 간손상 모델 HepG2/2E1 세포에서 오리나무 잎 추출물의 간보호효과

Bo-Ram Kim1†
,
Tae-Su Kim2†
,
Su Hui Seong1
,
Seahee Han1
,
Jin-Ho Kim1
,
Chan Seo1
,
Ha-Nul Lee1
,
Sua Im3
,
Jung Eun Kim3
,
Ji Min Jung3
,
Do-Yun Jeong3
,
Kyung-Min Choi4
,
Jin-Woo Jeong5
김 보람1†
,
김 태수2†
,
성 수희1
,
한 세희1
,
김 진호1
,
서 찬1
,
이 하늘1
,
임 수아3
,
김 정은3
,
정 지민3
,
정 도윤3
,
최 경민4
,
정 진우5
1Associate Researcher, Honam National Institute of Biological Resources, Mokpo 587262, Korea
2Senior Researcher, Honam National Institute of Biological Resources, Mokpo 587262, Korea
3Researcher, Honam National Institute of Biological Resources, Mokpo 587262, Korea
4Director, Honam National Institute of Biological Resources, Mokpo 587262, Korea
5General Manager, Honam National Institute of Biological Resources, Mokpo 587262, Korea
1국립호남권생물자원관, 전임연구원
2국립호남권생물자원관, 선임연구원
3국립호남권생물자원관, 연구원
4국립호남권생물자원관, 수석연구원
5국립호남권생물자원관, 책임연구원
*Corresponding Author
†These authors contributed equally to this work.
1 April 2024. pp. 120-129
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Abstract

Alcoholic liver disease (ALD) is a significant risk factor in the global disease burden. The stem bark of the Betulaceae plant Alnus japonica, which is indigenous to Korea, has been used as a popular folk medicine for hepatitis and cancer. However, the preventive effect of Alnus japonica leaf extracts on alcohol-related liver damage has not been investigated. The objective of this study was to investigate the hepatoprotective effects of the extracts of Alnus japonica leaf (AJL) against ethanol-induced liver damage in HepG2/2E1 cells. Treatment with AJL significantly prevented ethanol-induced cytotoxicity in HepG2/2E1 cells by reducing the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). This protective effect was likely associated with antioxidant potential of AJL, as evidenced by the attenuation of reactive oxygen species (ROS) and malondialdehyde (MDA) production and restoration of the depleted glutathione (GSH) levels in ethanol-induced HepG2/2E1 cells. Our findings suggest that FCC might be considered as a useful agent in the prevention of liver damage induced by oxidative stress by increasing the antioxidant defense mechanism.

Keywords
Alnus japonica leaf
Antioxidant
Hepatoprotective
HepG2/2E1 cells
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :2
  • Pages :120-129
  • Received Date : 2024-02-20
  • Revised Date : 2024-03-19
  • Accepted Date : 2024-03-20
  • DOI :https://doi.org/10.7732/kjpr.2024.37.2.120
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