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2021 Vol.34, Issue 6

Research Article

Undaria pinnatifida Inhibits the Mast Cell-Mediated Inflammatory Response via NF-κB/Caspase-1 Suppression
Yong-Deok Jeon1
,
Su-Hyun Lee2
,
Su-Jin Kim2*
1Professor, Department of Korean Pharmacy, Woosuk University, Wanju 55338, Korea
2Professor, Department of Biotechnology and Convergence, Daegu Haany University, Kyungsan 38578, Korea
*Corresponding Author
1 December 2021. pp. 503-509
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Abstract

Marine sources as potential treatment options for various diseases have been a subject of growing interest. However, information on the anti-inflammatory mechanism employed by Undaria pinnatifida (UP) remains limited. The present study was conducted to investigate the mechanisms of UP on the mast cell-mediated inflammatory response. To determine the pharmacological mechanism of UP in inflammatory reaction, we evaluated the effects of UP on interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α production and nuclear factor-κB (NF-κB) and caspase-1 activation in calcium ionophore A23187 plus phorbol 12-myristate 13-acetate-stimulated human mast cells-1 (HMC-1). The results showed that UP suppressed IL-6, IL-8 and TNF-α production in a dose-dependent manner. Moreover, UP significantly attenuated NF-kB/caspase-1 activation in stimulated HMC-1. Collectively, these findings provide experimental evidence that UP may be a useful candidate for the inflammation-related diseases treatment.

Keywords
Caspase-1
Inflammation
Inflammatory cytokines
Mast cells
Nuclear factor-κB
Undaria pinnatifida
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :6
  • Pages :503-509
  • Received Date : 2021-11-12
  • Revised Date : 2021-11-25
  • Accepted Date : 2021-11-26
  • DOI :https://doi.org/10.7732/kjpr.2021.34.6.503
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