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2022 Vol.35, Issue 4
The Regulatory Effect of Angelica gigas Nakai on Immune Enhancement and Cytokine Production in vivo and in vitro

참당귀(Angelica gigas Nakai)의 체력증진 및 면역조절효과

Yong-Deok Jeon1
,
Su-Jin Kim2*
전 용덕1
,
김 수진2*
1Professor, Department of Korean Pharmacy, Woosuk University, Wanju 55338, Korea
2Professor, Department of Biotechnology and Convergence, Daegu Haany University, Kyungsan 38578, Korea
1우석대학교 한약학과, 교수
2대구한의대학교 바이오산업융합학부, 교수
*Corresponding Author
1 August 2022. pp. 411-416
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Abstract

Natural products are important sources for drug development because they have a wide variety of useful biological properties. Angelica gigas Nakai (AGN) has been used as an herbal medicine for treatment of colds, pain, and anemia. The present study was designed to evaluate the regulatory effect of AGN on immune enhancement in vivo and in vitro. To investigate the immune-enhancing effect of AGN, we used forced swimming test (FST) experimental model. Mice were orally administered by AGN or distilled water for 14 days and then immobility time and biological parameters in serum were measured. The results showed that immobility time in AGN treatment group was significantly reduced in comparison with the control group. Plasma levels of blood urea nitrogen and lactate dehydrogenase in AGN group was significantly decreased compared with control group. Additionally, we showed that AGN treatment significantly increased immune-related cytokines such as interleukin (IL)-4, IL-2, and interferon (IFN)- levels in Molt-4 cells. Collectively, the findings provide experimental evidence that AGN may be effective in improving immune function.

Keywords
Angelica gigas Nakai
Immune enhancement
T cell
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 35
  • No :4
  • Pages :411-416
  • Received Date : 2022-02-08
  • Revised Date : 2022-05-17
  • Accepted Date : 2022-05-17
  • DOI :https://doi.org/10.7732/kjpr.2022.35.4.411
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