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2024 Vol.37, Issue 4

Research Article

세잎쥐손이풀(Geranium wilfordii Maxim.) 에탄올 추출물이 지방생성 및 지방합성에 미치는 영향

Effects of Geranium wilfordii Maxim. Ethanol Extract of on Adipogenesis and Lipogenesis

Tae Woo Kim1
,
Kyoung Kon Kim2
,
Jae Cheon Im2
,
Hye Rim Lee2
,
Jung Min Kim3
김 태우1
,
김 경곤2
,
임 재천2
,
이 혜림2
,
김 정민3
1Reserch Director, Newgen Healthcare Co., Ltd., Chuncheon 24232, Korea
2Head Resercher, Newgen Healthcare Co., Ltd., Chuncheon 24232, Korea
3Assistant Resercher, Newgen Healthcare Co., Ltd., Chuncheon 24232, Korea
1주식회사 뉴젠헬스케어 연구소장
2주식회사 뉴젠헬스케어 책임연구원
3주식회사 뉴젠헬스케어 주임연구원
*Corresponding Author
1 August 2024. pp. 307-313
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Abstract

In this study, the anti-obesity effect of Geranium wilfordii Maxim. extract was studied using 3T3-L1 cells. Geranium wilfordii Maxim. was extracted with water (NG-GT-T1L), 10% ethanol (NG-GT-T2L), 30% ethanol (NG-GT-T3L), 50% ethanol (NG-GT-T4L), 70% ethanol (NG-GT-T5L), and the effects on cell viability, lipid accumulation, triglyceride content, and protein expression in 3T3-L1 cells were confirmed. It was confirmed that NG-GT-T3L extract was superior to other extract conditions in reducing lipid accumulation and triglyceride content in the concentration range that did not show cytotoxicity. In addition, it was confirmed to suppress adipogenesis and lipogenesis by reducing the expression of peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT/enhancer binding protein-α(C/EBPα) proteins that regulate adipogenesis, decreasing the expression of fatty acid synthetase (FAS) and stearoyl CoA desaturase-1 (SCD-1) proteins that regulate lipogenesis, and increasing the expression of AMP-activated protein kinase (AMPK) protein. From these research results, Geranium wilfordii Maxim. NG-GT-T3L extract is believed to have anti-obesity reduction effects through suppressing lipid accumulation and triglyceride accumulation and regulating adipogenesis and lipogenesis-related proteins.

Keywords
AMPK
C/EBPα
Geranium wilfordii Maxim.
PPARγ
Triglyceride
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :4
  • Pages :307-313
  • Received Date : 2023-12-14
  • Revised Date : 2024-03-27
  • Accepted Date : 2024-04-08
  • DOI :https://doi.org/10.7732/kjpr.2024.37.4.307
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