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2025 Vol.38, Issue 2 Preview Page

Research Article

Inhibitory Activity of Lipid Accumulation Through β-Catenin-Mediated Suppression of PPARγ and CEBPα Expression by Leaf Extract of Sambucus racemosa subsp. pendula

말오줌나무(Sambucus racemosa subsp. pendula) 잎 추출물의 β-catenin 매개 PPARγ와 CEBPα의 발현 억제를 통한 지질축적 억제활성

Jeong Won Choi1†
,
Ji A Kim2†
,
Hyeok Jin Choi1
,
So Jung Park1
,
Sang Hun Lee1
,
Jin Hyuk Hwang1
,
Min Yeong Choi3
,
Gwang Hun Park4
,
Jin Boo Jeong5
최 정원1†
,
김 지아2†
,
최 혁진1
,
박 소정1
,
이 상훈1
,
황 진혁1
,
최 민영3
,
박 광훈4
,
정 진부5
1Graduate Student, Department of Forest Science, Andong National University, Andong 36729, Korea
2Senior Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Post-Master’s Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
5Professor, Department of Forest Science, Andong National University, Andong 36729, Korea
1국립안동대학교 산림과학과, 대학원생
2국립산림과학원 산림약용자원연구소, 연구관
3국립산림과학원 산림약용자원연구소, 석사후 연구원
4국립산림과학원 산림약용자원연구소, 연구사
5국립안동대학교 산림과학과, 교수
*Corresponding Author
†These authors contributed equally to this work.
1 April 2025. pp. 161-168
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Abstract

The purpose of this study was to investigate the anti-obesity activity and underlying mechanism of Sambucus racemosa subsp. pendula leaf (SRPL). Among various extracts, the 100% distilled water extract obtained at 20°C (AE20-SRPL) exhibited the highest lipid accumulation inhibitory activity. AE20-SRPL demonstrated lipid accumulation inhibitory effects only when treated during the early stage of preadipocyte differentiation into mature adipocytes. AE20-SRPL reduced the protein levels of PPARγ and CEBPα in a concentration-dependent manner. Additionally, AE20-SRPL increased the protein levels of β-catenin in a concentration-dependent manner, and knockdown of β-catenin attenuated AE20-SRPL-mediated reductions in PPARγ and CEBPα protein levels as well as lipid accumulation. These findings indicate that AE20-SRPL inhibits lipid accumulation by activating β-catenin, which subsequently decreases the protein levels of PPARγ and CEBPα.

Keywords
Adipogenesis
Anti-obesity
Sambucus racemosa subsp. pendula
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 38
  • No :2
  • Pages :161-168
  • Received Date : 2025-02-11
  • Accepted Date : 2025-02-26
  • DOI :https://doi.org/10.7732/kjpr.2025.38.2.161
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