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2022 Vol.35, Issue 6

Research Article

Immunostimulatory Activity of Hibiscus syriacus L. Leaves in Mouse Macrophages, RAW264.7 cells, and Immunosuppressed Mice
Na Gyeong Geum13
,
Ju Hyeong Yu1
,
So Jung Park1
,
Min Yeong Choi1
,
Jae Won Lee2
,
Gwang Hun Park3
,
Hae-Yun Kwon4
,
Jin Boo Jeong5*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Post-doc, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Researcher, Special Forest Resources Division, National Institute of Forest Science, Suwon 16631, Korea
5Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
*Corresponding Author
30 December 2022. pp. 697-703
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Abstract

Under the COVID-19 pandemic, interest in immune enhancement is increasing. Although the immune-enhancing activity of plants of the genus Hibiscus has been reported, there is no study on the immune-enhancing activity of H. syriacus. Thus, in this study, we investigated the immune-enhancing activity of Hibiscus syriacus leaves (HSL) in mouse macrophages, RAW264.7 cells, and immunosuppressed mice. HSL increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) and activated the phagocytosis in RAW264.7 cells. The HSL-mediated production of immunostimulatory factors was dependent on toll-like receptor 4 (TLR4), p38, and c-Jun N-terminal kinase (JNK) in RAW264.7 cells. In the immunosuppressed mouse model, HSL increased the spleen index, the levels of the cytokines, and the numbers of lymphocytes, neutrophils, and monocytes. Taken together, HSL may be considered to have immune-enhancing activity and be expected to be used as a potential immune-enhancing agent.

키워드
Hibiscus syriacus
Immune enhancement
Macrophages
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 35
  • No :6
  • Pages :697-703
  • Received Date : 2022-05-31
  • Revised Date : 2022-06-28
  • Accepted Date : 2022-06-28
  • DOI :https://doi.org/10.7732/kjpr.2022.35.6.697
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