Induction of Autophagy by Rosa acicularis Leaves Extracts in RAW264.7 Cells

Jeong Won Choi; Jin Boo Jeong

doi:10.7732/kjpr.2023.36.4.257

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2023 Vol.36, Issue 4 Next Page

Induction of Autophagy by Rosa acicularis Leaves Extracts in RAW264.7 Cells 인가목(Rosa acicularis Lindl.) 잎 추출물의 대식세포에서 자가포식 유도활성

1 August 2023. pp. 257-263

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Abstract

Autophagy contributes to enhancing the immune system (innate and adaptive immune system) against foreign pathogens. Autophagy of macrophages is used as a major indicator for developing vaccine adjuvants to increase the adaptive immune response. In this study, water extracts from Rosa acicularis leaves (RAL) increased the production of immunostimulatory mediators and phagocytic activity in RAW264.7 cells. RAL increased p62/SQSTM1 expression. Inhibition of TLR4, JNK, and PI3K/AKT blocked RAL-mediated increase of p62/SQSTM1. RAL activated JNK and PI3K/AKT signaling. RAL-mediated activations of JNK and PI3K/AKT signaling were reversed by TLR4 inhibition. Taken together, it is believed that RAL-mediated autophagy may be dependent on activating via TLR4-dependent activation of JNK and PI3K/AKT signaling in macrophages.

Keywords

Autophagy

Immunostimulation

Macrophages

Rosa acicularis Lindl.

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Information

Publisher :The Plant Resources Society of Korea
Publisher(Ko) :한국자원식물학회
Journal Title :Korean Journal of Plant Resources
Journal Title(Ko) :한국자원식물학회지
Volume : 36
No :4
Pages :257-263
Received Date : 2023-01-19
Revised Date : 2023-05-09
Accepted Date : 2023-05-15
DOI :https://doi.org/10.7732/kjpr.2023.36.4.257

Korean Journal of Plant Resources 한국자원식물학회지 ISSN:1226-3591(Print) 2287-8203(Online)

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