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2024 Vol.37, Issue 2

Research Article

The Photoprotective Effects of Gynura Procumbens Against Photoaging: A Comparative Study Based on Extraction Methods

추출방법에 따른 명월초(Gynura Procumbens)의 광노화 완화 효과

So Yeon Han1
,
Da Yoon Lee1
,
Ji Sun Moon2
,
Hye Won Lee3
,
Jae Hun Kim3
,
Jae Ho Park4
한 소연1
,
이 다윤1
,
문 지선2
,
이 혜원3
,
김 재훈3
,
박 재호4
1Graduate Student, Medicinal Plant Science, Jungwon University, Goesan 28027, Korea
2Professor, Department of Beauty Care, Jungwon University, Goesan 28027, Korea
3Researcher, MR INNOVATION Co., Ltd., Daegu 42251, Korea
4Professor, Department of Pharmaceutical Science, Jungwon University, Goesan 28027, Korea
1중원대학교 대학원 생명과학과, 대학원생
2중원대학교 의료뷰티케어학과, 교수
3㈜엠알이노베이션, 연구원
4중원대학교 식품제약학과, 교수
*Corresponding Author
1 April 2024. pp. 101-109
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Abstract

In this study, we investigated the antioxidant effects and active ingredients of Gynura Procumbens extracts obtained through various extraction methods for the development of natural-based cosmetics and pharmaceutical materials. The contents of compounds, total flavonoids, chlorogenic acid, and caffeic acid were compared at different concentrations, revealing the highest content of active ingredients in the 100% ethanol extract. Antioxidant activity assessed by DPPH and ABTS radical scavenging assays showed a concentration-dependent increase in antioxidant activity with the ethanol concentration. Additionally, we validated the DNA damage inhibition and anti-inflammatory effects of Gynura Procumbens extracts through UVB irradiation on Hs68 cell models. The 100% ethanol extract demonstrated significant inhibition of the expression of p-p53, γ-H2AX, iNOS, and COX-2 induced by UVB, indicating its potential in alleviating photodamage effects. Consequently, the efficient extraction of Gynura Procumbens for skin functional material development was confirmed, suggesting the suitability of ethanol or alcohol-based solvents.

Keywords
Anti-inflammatory
DNA damage
Gynura Procumbens
Photoaging
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :2
  • Pages :101-109
  • Received Date : 2024-01-29
  • Revised Date : 2024-03-04
  • Accepted Date : 2024-03-08
  • DOI :https://doi.org/10.7732/kjpr.2024.37.2.101
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