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2018 Vol.31, Issue 1

Research Article

Protective Effects of Flavonoids from the Boehmeria quelpaertense against H2O2-Induced Cytotoxicity in H9c2 Cardiomyoblast Cells

H9c2 심근세포에서 제주모시풀(Boehmeria quelpaertense)로부터 분리된 flavonoids의 H2O2로 유도된 독성 보호 효과

Kyeong-Wan Woo1*
,
Mi-Ok Sim1*
,
Ho Bak1
,
Ho Kyung Jung1
,
Byeongkwan An1
,
Seong-Ho Ham1
,
Jong Hyuk Park2
,
Hyun-Woo Cho1**
우 경완1*
,
심 미옥1*
,
박 호1
,
정 호경1
,
안 병관1
,
함 성호1
,
박 종혁2
,
조 현우1**
1Traditional Korean Medicines Research Team, Naional Development Institute of Korea Medicine
2Luco Co. Ltd
1한약진흥재단 한약자원본부 한약재연구팀
2(주)루코
*These authors contributed equally to this work.
** Corresponding Author
28 February 2018. pp. 1-9
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Abstract

As a part of an infrastructure project on medicinal herb-based remedies, we conducted a phytohemical investigation of the 100% MeOH extract from the aerial part of Boehmeria quelpaertense; our findings resulted in the isolation of flavonoids (1-2), isoquercitrin (1) and hyperoside (2). The identification and structural elucidation of these compounds were based on 1H-, 13C-NMR, and LC ESI IT-TOF MS data. All the compounds isolated from this plant were reported for the first time. In this study, we examined the antioxidant activity of the 1 and 2 on the hydrogen peroxide (H2O2)-induced oxidative stress in a Rat Cardiomyoblast cell line (H9c2). The pretreatment of the flavonoids showed that it protects against H2O2-mediated cell death in the H9c2 cell line. Also, it decreases the intracellular reactive oxygen species (ROS) levels by the flavonoids in the H2O2-treated H9c2 cell line. These results showed that the 1 and 2 are a source of antioxidants. As a result, they might be helpful in preventing the progress of various oxidative stress mediated diseases, including myocardial infarction.

Keywords
Anti-oxidant
Boehmeria quelpaertense
Flavonoid
Structure elucidation
Urticaceae
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :1
  • Pages :1-9
  • Received Date : 2017-08-07
  • Revised Date : 2017-09-19
  • Accepted Date : 2017-10-16
  • DOI :https://doi.org/10.7732/kjpr.2018.31.1.001
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