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2023 Vol.36, Issue 4 Preview Page
Protective Effect of Glycyrrhiza New Domestic Variety on the Acute Pancreatitis

국내 감초 신품종의 급성 췌장염 보호 효과

Dong-Gu Kim1
,
Kyung Hyun Min2*
김 동구1
,
민 경현2*
1Researcher, Department of Oriental Medicine Resources, Jeonbuk National University, Iksan 54596, Korea
2Professor, School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju 54896, Korea
1전북대학교 환경생명자원대학 한약자원학과, 연구원
2전북대학교 약학대학 약학과, 교수
*Corresponding Author
1 August 2023. pp. 282-289
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Abstract

Glycyrrhiza korshinskyi Grig. (Gk), which is a new variety of Glycyrrhiza, was developed by the National Institute of Horticultural and Herbal Science in Korea Rural Development Administration. It is improved the limitations of traditional Glycrrhiza species such as G. uralensis Fisch., G. glabra L., and G. inflata Batal. and has been reported various pharmacological effects. The aim of this study is to investigate the protective effect of Gk on the acute pancreatitis, because which has not been revealed yet. AP was induced via intraperitoneal injection of cerulein (50 ㎍/㎏) hourly for 7 times in C57BL/6 mice. Gk water extract (20 or 50 ㎎/㎏) or saline was administrated via oral gavage 1 h before the first injection of cerulein. The mice were sacrificed at 5 h after the final injection of cerulein. The inflammatory cell infiltration in pancreatic tissue was decreased by the administration of Gk water extract compared to the AP group. Also, serum amylase and lipase levels were decreased by the administration of Gk water extract compared to the AP group. These results suggest that Gk have protective effect on the acute pancreatitis.

Keywords
Acute pancreatitis
Cerulein
Glycyrrhiza
Glycyrrhiza korshinskyi Grig.
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 36
  • No :4
  • Pages :282-289
  • Received Date : 2023-04-24
  • Revised Date : 2023-04-27
  • Accepted Date : 2023-04-28
  • DOI :https://doi.org/10.7732/kjpr.2023.36.4.282
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