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2025 Vol.38, Issue 6 Preview Page

Research Article

Vasodilatory Properties of Complex Saponin Isolated from the Stem Bark Extract of Kalopanax pictus
Jung-Hwan Nam1
1Researcher, Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration, Pyeongchang 25342, Korea
*Corresponding Author
1 December 2025. pp. 657-664
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Abstract

The stem bark of Kalopanax pictus contains several bioactive constituents, including syringin, liriodendrin, saponin, and oleanolic acid. The stem bark of K. pictus has been conventionally utilized to manage ailments associated with arthritis, hypertension, and hemolysis, in addition to uses associated with its anti-nociceptive and anti-inflammatory characteristics. Nevertheless, the vasodilatory efficacy of complex saponin has yet to be empirically validated within a scientific framework. Consequently, the present investigation examined the vasodilatory properties of complex saponin extracted from K. pictus stem bark in rabbit basilar arteries. For this purpose, arterial rings with both intact and compromised endothelium were employed in an organ bath assay and exposed to endothelin-1 to induce contraction. Complex saponin, identified as the principal active compound within K. pictus stem bark extract, exerted a moderate vasodilatory effect on the basilar arteries of rabbits. Thus, complex saponin derived from K. pictus stem bark extract might preferentially enhance cerebral perfusion through the dilation of the basilar artery. Collectively, the results indicate that complex saponin might potentially be utilized as a vasodilatory agent.

Keywords
Complex saponin
Endothelin
Kalopanax pictus
Stem bark
Vasodilatory
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 38
  • No :6
  • Pages :657-664
  • Received Date : 2025-10-14
  • Revised Date : 2025-11-05
  • Accepted Date : 2025-11-06
  • DOI :https://doi.org/10.7732/kjpr.2025.38.6.657
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