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2024 Vol.37, Issue 6 Preview Page

Research Article

Jeju Lava Seawater Enhances Anti-inflammatory Activity of Litsea japonica Fruit in LPS-Stimulated RAW 264.7 Cells
Boram Go1
,
Seon-A Yoon2
,
Sung Chun Kim2
,
Ho Bong Hyun1
,
Hyejin Hyeon1
,
So Yeon Oh1
,
Young Kyu Lee3
,
Ha Jeong Boo3
,
Young-Hwan Jung4
,
Ki Ju Kim5
,
Young-min Ham6
,
Weon-Jong Yoon6
1Researcher, Biodiversity Research Institute, Clean Bio Business Division, Jeju Technopark, Seogwipo 63608, Korea
2Senior Researcher, Biodiversity Research Institute, Clean Bio Business Division, Jeju Technopark, Seogwipo 63608, Korea
3Researcher, Yong-am-hae-su Center, Clean Bio Business Division, Jeju Technopark, Jeju 63359, Korea
4Division Director, Biodiversity Research Institute, Clean Bio Business Division, Jeju Technopark, Seogwipo 63608, Korea
5Team Leader, Yong-am-hae-su Center, Clean Bio Business Division, Jeju Technopark, Jeju 63359, Korea
6Team Leader, Biodiversity Research Institute, Clean Bio Business Division, Jeju Technopark, Seogwipo 63608, Korea
*Corresponding Author
1 December 2024. pp. 562-568
PDF XML Citation
Abstract

Litsea japonica fruit has been reported uses to relief bone pain, inflammation, and asthma. In a previous study, we demonstrated that Litsea japonica fruit extract (LFE) exerts anti-inflammatory activity by suppressing NO, iNOS, and COX-2 levels in LPS-stimulated murine macrophage RAW 264.7 cells. This article aimed to address the synergistic effects of Jeju Lava Seawater (JLS) and LFE on anti-inflammatory activity. JLS was optimized to exhibit a Ca:Mg ratio of 2:1 and water hardness of 1,000 ppm. Combined treatment showed stronger inhibition of NO production and iNOS and COX-2 expression compared to the LFE-only treated group. Furthermore, the combined treatment also downregulated the phosphorylation of MAPK/NF-κB and degradation of IκB-α. This investigation indicates that JLS, containing trace elements such as Ca and Mg, would enhance the anti-inflammatory activity of LFE.

Keywords
Anti-inflammation
Jeju Lava Seawater
Litsea japonica fruit
RAW 264.7 cells
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :6
  • Pages :562-568
  • Received Date : 2024-07-09
  • Revised Date : 2024-08-09
  • Accepted Date : 2024-08-12
  • DOI :https://doi.org/10.7732/kjpr.2024.37.6.562
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