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2024 Vol.37, Issue 3 Preview Page

Research Article

The Anti-inflammatory Mechanism of Blueberry is through Suppression of NF-kB/Caspase-1 Activation in LPS-induced RAW264.7 Cells
Mi-Ok Yang1
,
Noh-Yil Myung2
1Professor, Wonkwang Institute of Nature Healthcare Studies, Iksan 54538, Korea
2Professor, Department of Korean Medicine and Food Therapy, Wonkwang Digital University, Iksan 54538, Korea
*Corresponding Author
1 June 2024. pp. 256-262
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Abstract

Blueberry (BB), fruit of Vacciniumi, has been hailed as an antioxidant superfood. BB is a rich source of vitamins, minerals, flavonoids, phenolic acids and known to have a variety of pharmacological actions. The purpose of this work is to clarify the anti-inflammatory mechanism of BB in lipopolysaccharide (LPS)-activated RAW264.7 macrophage. We explored the effects of BB on the production of inflammatory cytokines, prostaglandin E2 (PGE2) and expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 macrophage. Moreover, to investigate the molecular mechanisms by BB, we evaluated whether BB modulate nuclear factor-kappa B (NF)-kB pathway and caspase- 1 activation. The findings of this work demonstrated that BB alleviated the LPS-enhanced inflammatory cytokines and PGE2, as well as COX-2 levels. Additionally, we demonstrated that the anti-inflammatory mechanism of BB occurs due to the attenuation of IκB-α degradation, NF-kB translocation and caspase-1 activation. Conclusively, these findings provide evidence that BB may be useful agents in the treatment of inflammation.

Keywords
Blueberry
Caspase-1
Inflammation
Nuclear factor-kappa B
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :3
  • Pages :256-262
  • Received Date : 2024-04-22
  • Revised Date : 2024-05-08
  • Accepted Date : 2024-05-16
  • DOI :https://doi.org/10.7732/kjpr.2024.37.3.256
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