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2025 Vol.38, Issue 6

Research Article

The Improving Effects of Pu-erh Tea on Atopic Dermatitis in vivo and in vitro
Su-Jin Kim1
1Professor, Department of Biotechnology and Convergence, Daegu Haany University, Gyeongsan, Korea
*Corresponding Author
1 December 2025. pp. 641-648
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Abstract

Pu-erh tea, a world-famous tea, has many health-benefit properties including anti-oxidant, anti-cancer and anti-obesity properties. This study aimed to investigate the pharmacological effect of Pu-erh tea on atopic dermatitis (AD) in vivo and in vitro. We investigated the effects of Pu-erh tea on 2, 4-dinitrochlrobenzene (DNCB)-induced AD clinical symptoms in mice. Additionally, we evaluated the effects of Pu-erh tea on the inflammatory cytokine production and nuclear factor-κB (NF-kB) activation in HaCaT cells. The findings demonstrated that Pu-erh tea improved the AD clinical symptoms, such as erythema, skin dryness, eczematous, and inhibited the serum levels of histamine and IgE in DNCB-induced AD model. Moreover, Pu-erh tea attenuated the inflammatory cytokine production and NF-kB activation in HaCa T cells. Collectively, this result suggests that Pu-erh tea could be used as a therapeutic agent for AD treatment.

Keywords
Atopic dermatitis
HaCaT cells
Nuclear factor-κB
Pu-erh tea
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 38
  • No :6
  • Pages :641-648
  • Received Date : 2025-06-25
  • Revised Date : 2025-07-09
  • Accepted Date : 2025-07-10
  • DOI :https://doi.org/10.7732/kjpr.2025.38.6.641
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