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2024 Vol.37, Issue 5 Preview Page

Research Article

Inhibitory Effect of Nicotiana debneyi against the Melanogenesis

야생종 담배 추출물(Nicotiana debneyi)의 멜라닌생성 억제효과

Sang Hun Lee1†
,
Song-Yi Park2†
,
Jeong Won Choi1
,
Hyeok Jin Choi1
,
So Jung Park1
,
Jin Hyuk Hwang1
,
Jeong Heon Lee2
,
Kwang Chul Kim2
,
Cheol Bin An2
,
Jin Boo Jeong3
이 상훈1†
,
박 송이2†
,
최 정원1
,
최 혁진1
,
박 소정1
,
황 진혁1
,
이 정헌2
,
김 광철2
,
안 철빈2
,
정 진부3
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Researcher, KT&G R&D Headquarters, Daejeon 34128, Korea
3Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 산림과학과, 대학원생
2KT&G R&D 본부, 연구원
3국립안동대학교 산림과학과, 교수
*Corresponding Author
†These authors contributed equally to this work.
1 October 2024. pp. 455-460
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Abstract

This study aimed to evaluate the potential use of 50% ethanol extract from the aerial parts of N. debneyi (ND50E) as a whitening cosmetic ingredient by assessing its inhibitory activity on melanin production. The results demonstrated that ND50E significantly suppressed both extracellular and intracellular melanin production. Additionally, ND50E had no effect on the expression of tyrosinase mRNA, but it significantly reduced the protein level of tyrosinase. These findings suggest that ND50E inhibits melanin production by decreasing the protein level of tyrosinase. Therefore, ND50E holds significant potential as an effective melanin production inhibitor for use in whitening cosmetic formulations.

Keywords
Melanin
Melanogenesis
Nicotiana debneyi
Whitening
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 37
  • No :5
  • Pages :455-460
  • Received Date : 2024-08-26
  • Revised Date : 2024-09-02
  • Accepted Date : 2024-09-02
  • DOI :https://doi.org/10.7732/kjpr.2024.37.5.455
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