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2021 Vol.34, Issue 1 Preview Page

Research Article

Development of HPLC Method for Quality Assessment of Marker Components in Atractylodis Rhizoma Alba

백출(Atractylodis Rhizoma Alba)의 품질평가를 위한 지표성분 분석법 평가

Jae-Woong Lee1
,
Joon-Hee Kim2
,
Byoung-Man Kang1
,
Byung-Kwan Ahn3†
이 재웅1
,
김 준희2
,
강 병만1
,
안 병관3†
1Researcher, Medicinal Crops Seed Supply Center, National Development Institute of Korean Medicine, Jangheung 59338, Korea
2Associate Researcher, Medicinal Crops Seed Supply Center, National Development Institute of Korean Medicine, Jangheung 59338, Korea
3Senior Researcher, Medicinal Crops Seed Supply Center, National Development Institute of Korean Medicine, Jangheung 59338, Korea
1한국한의약진흥원 한약자원개발본부 약용작물종자보급센터, 선임연구원
2한국한의약진흥원 한약자원개발본부 약용작물종자보급센터, 주임연구원
3한국한의약진흥원 한약자원개발본부 약용작물종자보급센터, 책임연구원
*lee0210@nikom.or.kr
1 February 2021. pp. 52-58
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Abstract

Homogenization of quality was important in order to use herbal medicines as pharmaceuticals. To solve this problem, it was important to establish quality standards. Atractylodis Rhizoma Alba has no quantitative method in the Korean Pharmacopoeia. Thus, we have researched to improve the quality evaluation method of Atractylodis Rhizoma Alba with an HPLC. Atractylenolide Ⅲ and atracylodin were selected as potential marker compounds. This analytical procedure was subject to validation. According to validation guideline of South Korea’s Ministry of Food and Drugs Safety, the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy were measured. Because the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy meet criteria of the guideline, the analytic method was validated. With this analysis, Atractylodis Rhizoma Alba and Atractylodis Rhizoma analyzed. As a result, both atractylenolide Ⅲ and atracylodin appear to be suitable standard compounds. it confirmed that tractylodes Rhizome, similar to Atractylodes Rhizome Alba, could be distinguished.

Keywords
Analysis
Atractylenolide Ⅲ
Atractylodes macrocephala Koidzum
Atracylodin
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :1
  • Pages :52-58
  • Received Date : 2020-06-27
  • Revised Date : 2020-10-29
  • Accepted Date : 2020-11-05
  • DOI :https://doi.org/10.7732/kjpr.2021.34.1.052
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