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2021 Vol.34, Issue 1 Preview Page

Research Article

Anti-inflammatory Effect of Berchemia berchemiaefolia Leaves through Inhibition of NF-κB and MAPK Signaling Activation in LPS-stimulated RAW264.7 Cells

망개나무 추출물의 NF-κB 및 MAPK 신호전달 억제를 통한 항염증 효과

Da Som Kim1
,
Hyun Ji Eo2
,
Yeongyeong Kang1
,
Gwang Hun Park3†
김 다솜1
,
어 현지2
,
강 연경1
,
박 광훈3†
1Master’s Degree Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
2Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
1국립산림과학원 산림약용자원연구소 석사연구원
2국립산림과학원 산림약용자원연구소 박사연구원
3국립산림과학원 산림약용자원연구소 연구사
*ppkh0230@korea.kr
1 February 2021. pp. 31-36
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Abstract

Berchemia berchemiaefolia (Makino) Koidz. is found not only in korea, but also in japan and is known as a rare plant all over the world. In this study, we evaluated anti-inflammatory effect of B. berchemiaefolia (Makino) Koidz. leaves (BBK-L) in LPS-stimulated RAW264.7 cells. BBK-L inhibited the generation of NO through the suppression of iNOS experession. BBK-L attenuated the expression of iNOS, COX-2, TNF-α, IL-1β, IL-6 induced by LPS. BBK-L decreased LPS-mediated IκB-α degradation inhibite which resulted in the inhibition of NF-κB activation in RAW264.7 cells. In addition, BBK-L suppressed ERK1/2, JNK phosphorylation induced by LPS. BBK-L showed anti-inflammatory effect through blocking the generation of the inflammatory mediators such as NO, iNOS, COX-2 , TNF-α , IL-1β, IL-6 via the inhibiting of NF-κB and MAPK signaling activation. These results suggests that BBK-L may have great potential for the development of anti-inflammatory drug to treat acute and chronic inflammatory disorders.

Keywords
Anti-inflammatory activity
Berchemia berchemiaefolia Koidz
Pro-inflammatory cytokine
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 34
  • No :1
  • Pages :31-36
  • Received Date : 2020-09-10
  • Revised Date : 2020-11-27
  • Accepted Date : 2020-12-15
  • DOI :https://doi.org/10.7732/kjpr.2021.34.1.031
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